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19 posts · 2 links · 22 releases
R/Pharma 2026 · Keynote · October What can we actually do with AI agents right now? Prepared in the open — follow the developer diary →

October 20262 posts · 2 links · 8 releases

  • Oct 27 Prompting to a KeynoteA friend asked how I built the slides for my R/Pharma 2026 keynote. The short answer is one prompt at a time. Here are the ones that mattered.
  • Oct 21 R/Pharma Diary #10 — What Can We Actually Do With AI Agents Right Now? The keynote, annotatedThis morning I’m giving the keynote at R/Pharma 2026. This is the talk, slide by slide, with what I’ll say about each one.
  • Oct 18 How employment is changing at Anthropic anthropic.com“What transformations of work and employment can we expect under increasingly powerful AI? Anthropic is worth studying because it has thoroughly molded its workflows around AI. Agents flit through ... Note →
  • Oct 18 How the Claude Code team does code review / claude.dev Blog claude.dev Blog“We think "did a human read the code?" is an imprecise proxy for "what could go wrong with this change, and which check—automated or human—is the right one to catch it?" Asking that question also c... Note →
  • Oct 15 safety.viz v1.11.2 Hep Explorer sizes points by the new R ratio (nR), which the original renderer offered NotesDemoWalkthrough
  • Oct 14 safety.viz v1.11.1 Demo app: Start R from a note on each card, and one colour scheme for notes across the app NotesDemoWalkthrough
  • Oct 10 safety.viz v1.11.0 Demo app made ready to show: an Exploratory label with status tiers, one R control, review fixes NotesDemoWalkthrough
  • Oct 9 safety.viz v1.10.0 RBQM tab in the demo app: gsm's site metrics run by R in your browser, drawn with gsm.viz (Experimental) NotesDemoWalkthrough
  • Oct 7 safety.viz v1.9.2 Run the demo app locally with one script; a cross-tabulation chart; group comparison opens on trends NotesDemoWalkthrough
  • Oct 4 safety.viz v1.9.1 Demo app says what happens to your data; the histogram's JavaScript p-values are deprecated NotesDemoWalkthrough
  • Oct 3 safety.viz v1.9.0 Biomarkers tab: bio.viz's four charts in the demo app, R's tests on request, a shared chart kit NotesDemoWalkthrough
  • Oct 2 safety.viz v1.8.0 Demo app: load your own study in the browser, map its columns, draw 13 charts; nine legacy requests NotesDemoWalkthrough

September 20261 post

August 20261 post · 3 releases

July 20264 posts · 10 releases

  • Jul 26 safety.viz v1.5.0 Participant Profile drill-down on six charts, the Hepatic ALT Waterfall, an eDISH migration Sankey NotesDemoWalkthrough
  • Jul 23 gsm.safety v1.0.0 First stable release: nine safety.viz charts as htmlwidgets, with demo data and gsm workflows NotesDemo
  • Jul 22 safety.viz v1.4.1 Consistent QT demo data; hep-explorer and qt-explorer share one view selector NotesDemo
  • Jul 18 safety.viz v1.4.0 QT Safety Explorer, phase 1: Δ/ΔΔ central tendency with CIs, outlier scatter, categorical table NotesDemo
  • Jul 17 R/Pharma Diary #7 — Papers → Prompts → PrototypesI demoed safety.viz for safetyGraphics’ clinical lead, Jim Buchanan, this week and asked if he had any improvements in mind, and no surprise, he had a few! Jim promptly sent a h...
  • Jul 16 safety.viz v1.3.1 Evidence pages show the reviewed requirement text beside each ID, checked in CI NotesDemo
  • Jul 16 safety.viz v1.3.0 Adverse Event Explorer: hierarchical incidence table with per-arm rates and drill-through NotesDemo
  • Jul 13 safety.viz v1.2.0 Hepatic Safety Explorer (eDISH) with participant drill-down, and the first clinical guide NotesDemo
  • Jul 13 R/Pharma Diary #6 — Obot v3: How I Used a Billion Tokens in a WeekendI introduced Obot 🍊😺 a few posts back and described how I set it up with OpenClaw and Telegram.1 My original readout — “51% fun / 49% frustrating” — still stands. That’s clearly...
  • Jul 12 safety.viz v1.1.0 All-measures overview for the histogram; demo data from a scripted pharmaverse pipeline NotesDemo
  • Jul 12 safety.viz v1.0.0 First stable release: six interactive charts with data contracts, demos and test evidence NotesDemo
  • Jul 12 R/Pharma Diary #5 — Introducing safety.vizMy last post laid out the plan for {safetyGraphics} v2 and ended on the obvious question: can we actually do this? Here’s the first big answer: safety.viz is live.1 A...
  • Jul 11 safety.viz v0.1.0 Safety-histogram pilot as a library module, plus the shared renderer shell NotesDemo
  • Jul 2 R/Pharma Diary #4 — safetyGraphics ❤️ gsmSo, here’s the plan for {safetyGraphics} v2.1 AI collaboration note — I outlined this post in June. Claude Code (using Fable 5) expanded my outline into a draft, and ...

June 20263 posts

May 20261 release

  • May 15 gsm.safety v0.1.0 Experimental bridge: first proof that {safetyGraphics} charts could run from {gsm} workflows Notes

April 20263 posts

February 20263 posts

  • Feb 25 Agentic Pattern: First Run the TestsI really like Simon Willison’s new series on agentic engineering patterns. If you’re using coding agents day-to-day, this feels like required reading:
  • Feb 16 Something Big is HappeningThis article, “Something Big Is Happening” from Matt Shumer, is a practical take on the current state of AI, and it very closely describes how I’ve been feeling the last few mon...
  • Feb 10 Five Levels of AI-Assisted DevelopmentI found this post outlining 5 levels of AI adoption (full original post here) to be very interesting. Here are the levels:

April 20231 post

  • Apr 14 Website refactor with GPT4The website for my main open source project is waaaay overdue for a refactor. Development on the project is still pretty active, but the content on the site is pretty out of dat...

March 20231 post

  • Mar 29 Shiny GPT DemoI asked ChatGPT to make me a little Issue Management Shiny App. Here’s how it went! Some of the resulting code is in this repo.